Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2007-09-06
The Journal of Physical Chemistry B 111 (2007) 10357-10364
Physics
Condensed Matter
Soft Condensed Matter
Scientific paper
10.1021/jp0731710
In this work the physicochemical characterization of liposomes loaded with a newly synthesised carboranyl porphyrazine (H2HECASPz) is described. This molecule represents a potential drug for different anticancer therapies, such as Boron Neutron Capture Therapy, Photodynamic Therapy and Photothermal Therapy. Different loading methods and different lipid mixtures were tested. The corresponding loaded vectors were studied by Small Angle Scattering (SANS and SAXS), light scattering and zeta potential. The combined analysis of structural data at various length scales and the measurement of the surface charge allowed to obtain a detailed characterization of the investigated systems. The mechanisms underlying the onset of differences in relevant physicochemical parameters (size, polydispersity and charge) were also critically discussed.
Giustini Mauro
Martini Giacomo
Oberdisse Julian
Pietrangeli Daniela
Ricciardi Giampaolo
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