Size-dependent rheology of type-I collagen networks

Details Size-dependent rheology of type-I collagen networks Size-dependent rheology of type-I collagen networks

2010-08-13

arxiv.org/abs/1008.2360v1

Physics

Condensed Matter

Soft Condensed Matter

3 pages, 4 figures, to appear in Biophysical Journal Letters, September 2010

Scientific paper

We investigate the system size dependent rheological response of branched type I collagen gels. When subjected to a shear strain, the highly interconnected mesh dynamically reorients, resulting in overall stiffening of the network. When a continuous shear strain is applied to a collagen network, we observe that the local apparent modulus, in the strain-stiffening regime, is strongly dependent on the gel thickness. In addition, we demonstrate that the overall network failure is determined by the ratio of the gel thickness to the mesh size. These findings have broad implications for cell-matrix interactions, the interpretation of rheological tissue data, and the engineering of biomimetic scaffolds.

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