Simulations of living filaments

Details Simulations of living filaments Simulations of living filaments

2012-02-28

arxiv.org/abs/1202.6327v1

Physics

Condensed Matter

Soft Condensed Matter

18 pages, 10 figures, Accepted for publication in J. Chem. Phys

Scientific paper

We propose a hybrid Molecular Dynamics/Multi-particle Collision Dynamics model to simulate a set of self-assembled semiflexible filaments and free monomers. Further, we introduce a Monte-Carlo scheme to deal with single monomer addition (polymerization) or removal (depolymerization), satisfying the detailed balance condition within a proper statistical mechanical framework. This model of filaments, based on the wormlike chain, aims to represent equilibrium polymers with distinct reaction rates at both ends, such as self-assembled ADP-actin filaments in the absence of ATP hydrolysis and other proteins. We report the distribution of filament lengths and the corresponding dynamical fluctuations on an equilibrium trajectory. Potential generalizations of this method to include irreversible steps like ATP-actin hydrolysis are discussed.

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