Sensing DNA - DNA as nanosensor: a perspective towards nanobiotechnology

Details Sensing DNA - DNA as nanosensor: a perspective towards nanobiotechnology Sensing DNA - DNA as nanosensor: a perspective towards nanobiotechnology

2005-08-20

arxiv.org/abs/cond-mat/0508490v1

Physics

Condensed Matter

Soft Condensed Matter

7 pages REVTeX, 7 eps figures. Journal of Computational and Theoretical Nanoscience, at press

Scientific paper

Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employing single molecule fluorescence methods, we propose to make use of the physics of DNA denaturation nanoregions to find out about the solvent conditions such as ionic strength, presence of binding proteins, etc. By measuring dynamical quantities in particular, rather sensitive nanoprobes may be constructed with contemporary instruments.

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