Selection, Mutations and Codon Usage in Bacterial Model

Details Selection, Mutations and Codon Usage in Bacterial Model Selection, Mutations and Codon Usage in Bacterial Model

1998-08-28

arxiv.org/abs/cond-mat/9808317v1

J. theor. Biol. 173, 271-281 (1995)

Physics

Condensed Matter

Statistical Mechanics

15 pages, 3 figures

Scientific paper

10.1006/jtbi.1995.0062

We present a statistical model of bacterial evolution based on the coupling between codon usage and tRNA abundance. Such a model interprets this aspect of the evolutionary process as a balance between the codon homogenization effect due to mutation process and the improvement of the translation phase due to natural selection. We develop a thermodynamical description of the asymptotic state of the model. The analysis of naturally occurring sequences shows that the effect of natural selection on codon bias not only affects genes whose products are largely required at maximal growth rate conditions but also gene products that undergo rapid transient increases.

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