Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2007-08-14
International Journal of Modern Physics C 20 (6), 817-830 (2009)
Physics
Condensed Matter
Statistical Mechanics
Final published version
Scientific paper
10.1142/S0129183109014023
For most of the important processes in DNA metabolism, a protein has to reach a specific binding site on the DNA. The specific binding site may consist of just a few base pairs while the DNA is usually several millions of base pairs long. How does the protein search for the target site? What is the most efficient mechanism for a successful search? Motivated by these fundamental questions on intracellular biological processes, we have developed a model for searching a specific site on a model DNA by a single protein. We have made a comparative quantitative study of the efficiencies of sliding, inter-segmental hoppings and detachment/re-attachments of the particle during its search for the specific site on the DNA. We also introduce some new quantitative measures of {\it efficiency} of a search process by defining a relevant quantity, which can be measured in {\it in-vitro} experiments.
No associations
LandOfFree
Searching for targets on a model DNA: Effects of inter-segment hopping, detachment and re-attachment does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Searching for targets on a model DNA: Effects of inter-segment hopping, detachment and re-attachment, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Searching for targets on a model DNA: Effects of inter-segment hopping, detachment and re-attachment will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-389790