Rocking ratchet based on F1-ATPase in the absence of ATP

Details Rocking ratchet based on F1-ATPase in the absence of ATP Rocking ratchet based on F1-ATPase in the absence of ATP

2009-01-08

arxiv.org/abs/0901.0979v1

Physics

Condensed Matter

Soft Condensed Matter

5 pages, 6 figures

Scientific paper

Bartussek, Hanggi and Kissner studied a rocking ratchet system, in which a Brownian particle is subject to an asymmetric periodic potential together with an oscillating force, and found that the direction of the macroscopic current can be reversed by changing the parameter values characterizing the model [Europhys. Lett., 28 (1994) 459]. In this letter, we apply their ratchet theory to a rotary motor-protein, F1-ATPase. In this work, we construct a model of a rocking ratchet in which F1-ATPase rotates not as a result of ATP hydrolysis but through the influence of an oscillating force. We then study the motion of F1-ATPase on the basis of molecular dynamics simulations of this coarse-grained protein model. Although in the absence of ATP, F1-ATPase exhibits directionless Brownian motion when there exists no oscillating force, we observe directional motion when we do apply an oscillating force. Furthermore, we observe that the direction of rotation is reversed when we change the oscillation frequency.

Affiliated with

Also associated with

No associations

Rating

Rocking ratchet based on F1-ATPase in the absence of ATP does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Rocking ratchet based on F1-ATPase in the absence of ATP, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rocking ratchet based on F1-ATPase in the absence of ATP will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-62248