Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2009-04-17
Physics
Condensed Matter
Statistical Mechanics
6 pages, 7 figures
Scientific paper
Polymerization of RNA from a template DNA is carried out by a molecular machine called RNA polymerase (RNAP). It also uses the template as a track on which it moves as a motor utilizing chemical energy input. The time it spends at each successive monomer of DNA is random; we derive the exact distribution of these "dwell times" in our model. The inverse of the mean dwell time satisfies a Michaelis-Menten-like equation and is also consistent with a general formula derived earlier by Fisher and Kolomeisky for molecular motors with unbranched mechano-chemical cycles. Often many RNAP motors move simultaneously on the same track. Incorporating the steric interactions among the RNAPs in our model, we also plot the three-dimensional phase diagram of our model for RNAP traffic using an extremum current hypothesis.
Chowdhury Debashish
Schütz Gunter M.
Tripathi Tripti
No associations
LandOfFree
RNA polymerase motors: dwell time distribution, velocity and dynamical phases does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with RNA polymerase motors: dwell time distribution, velocity and dynamical phases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and RNA polymerase motors: dwell time distribution, velocity and dynamical phases will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-140851