Recovery of free energy branches in single molecule experiments

Details Recovery of free energy branches in single molecule experiments Recovery of free energy branches in single molecule experiments

2009-01-25

arxiv.org/abs/0901.3886v1

Phys. Rev. Lett. 102, 070602 (2009)

Physics

Condensed Matter

Soft Condensed Matter

To appear in Phys. Rev. Lett. 4 pages + Supp. Mat. (6 pages)

Scientific paper

10.1103/PhysRevLett.102.070602

We present a method for determining the free energy of coexisting states from irreversible work measurements. Our approach is based on a fluctuation relation that is valid for dissipative transformations in partially equilibrated systems. To illustrate the validity and usefulness of the approach, we use optical tweezers to determine the free energy branches of the native and unfolded states of a two-state molecule as a function of the pulling control parameter. We determine, within 0.6 kT accuracy, the transition point where the free energies of the native and the unfolded states are equal.

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