Protein-mediated Loops and Phase Transition in Nonthermal Denaturation of DNA

Details Protein-mediated Loops and Phase Transition in Nonthermal Denaturation of DNA Protein-mediated Loops and Phase Transition in Nonthermal Denaturation of DNA

2009-12-21

arxiv.org/abs/0912.4122v1

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 2 figures

Scientific paper

We use a statistical mechanical model to study nonthermal denaturation of DNA in the presence of protein-mediated loops. We find that looping proteins which randomly link DNA bases located at a distance along the chain could cause a first-order phase transition. We estimate the denaturation transition time near the phase transition, which can be compared with experimental data. The model describes the formation of multiple loops via dynamical (fluctuational) linking between looping proteins, that is essential in many cellular biological processes.

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