Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks

Details Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks

2009-06-24

arxiv.org/abs/0906.4385v1

Phys. Rev. E 81 (2010) 051907

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 6 figures

Scientific paper

We employ simulations of model proteins to study folding on rugged energy landscapes. We construct ``first-passage'' networks as the system transitions from unfolded to native states. The nodes and bonds in these networks correspond to basins and transitions between them in the energy landscape. We find power-laws between the folding time and number of nodes and bonds. We show that these scalings are determined by the fractal properties of first-passage networks. Reliable folding is possible in systems with rugged energy landscapes because first passage networks have small fractal dimension.

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