Propagation of external regulation and asynchronous dynamics in random Boolean networks

Physics – Condensed Matter – Statistical Mechanics

Scientific paper

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19 pages, 14 figures, to appear in Chaos

Scientific paper

10.1063/1.2742931

Boolean Networks and their dynamics are of great interest as abstract modeling schemes in various disciplines, ranging from biology to computer science. Whereas parallel update schemes have been studied extensively in past years, the level of understanding of asynchronous updates schemes is still very poor. In this paper we study the propagation of external information given by regulatory input variables into a random Boolean network. We compute both analytically and numerically the time evolution and the asymptotic behavior of this propagation of external regulation (PER). In particular, this allows us to identify variables which are completely determined by this external information. All those variables in the network which are not directly fixed by PER form a core which contains in particular all non-trivial feedback loops. We design a message-passing approach allowing to characterize the statistical properties of these cores in dependence of the Boolean network and the external condition. At the end we establish a link between PER dynamics and the full random asynchronous dynamics of a Boolean network.

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