Probing protein-protein interactions by dynamic force correlated spectroscopy (FCS)

Details Probing protein-protein interactions by dynamic force correlated spectroscopy (FCS) Probing protein-protein interactions by dynamic force correlated spectroscopy (FCS)

2005-09-05

arxiv.org/abs/cond-mat/0509115v1

Physics

Condensed Matter

Soft Condensed Matter

12 pages, 3 figures, accepted to Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.95.168302

We develop a formalism for single molecule dynamic force spectroscopy to map the energy landscape of protein-protein complex ($P_1$$P_2$). The joint distribution $P(\tau_1,\tau_2)$ of unbinding lifetimes $\tau_1$ and $\tau_2$ measurable in a compression-tension cycle, which accounts for the internal relaxation dynamics of the proteins under tension, shows that the histogram of $\tau_1$ is not Poissonian. The theory is applied to the forced unbinding of protein $P_1$, modeled as a wormlike chain, from $P_1$$P_2$. We propose a new class of experiments which can resolve the effect of internal protein dynamics on the unbinding lifetimes.

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