Physical limits on computation by assemblies of allosteric proteins

Details Physical limits on computation by assemblies of allosteric proteins Physical limits on computation by assemblies of allosteric proteins

2008-02-07

arxiv.org/abs/0802.1034v2

Physics

Condensed Matter

Soft Condensed Matter

6 pages, 3 figures. 2 pages of supplemental information

Scientific paper

10.1103/PhysRevLett.101.178104

Assemblies of allosteric proteins, nano-scale Brownian computers, are the principle information processing devices in biology. The troponin C-troponin I (TnC-TnI) complex, the Ca$^{2+}$-sensitive regulatory switch of the heart, is a paradigm for Brownian computation. TnC and TnI specialize in sensing (reading) and reporting (writing) tasks of computation. We have examined this complex using a newly developed phenomenological model of allostery. Nearest-neighbor-limited interactions among members of the assembly place previously unrecognized constrains the topology of the system's free energy landscape and generate degenerate transition probabilities. As a result, signaling fidelity and deactivation kinetics can not be simultaneously optimized. This trade-off places an upper limit on the rate of information processing by assemblies of allosteric proteins that couple to a single ligand chemical bath.

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