Physics – Condensed Matter – Materials Science
Scientific paper
2009-01-31
J. Am. Chem. Soc., 2009, 131 -1-, pp 289
Physics
Condensed Matter
Materials Science
Scientific paper
10.1021/ja807307e
Nanomaterials hold much promise for biological applications, but they require appropriate functionalization to provide biocompatibility in biological environments. For non-covalent functionalization with biocompatible polymers, the polymer must also remain attached to the nanomaterial after removal of its excess to mimic the high dilution conditions of administration in vivo. Reported here are the synthesis and utilization singly-substituted conjugates of dextran and a phospholipid (Dextran-DSPE) as stable coatings for nanomaterials. Suspensions of single walled carbon nanotubes were found not only to be stable to phosphate buffered saline (PBS), serum, and a variety of pHs after excess polymer removal, but also provide brighter photoluminescence than carbon nanotubes suspended by poly(ethylene glycol)-DSPE. In addition, both gold nanoparticles (AuNPs) and gold nanorods (AuNRs) were found to maintain their dispersion and characteristic optical absorbance after transfer into Dextran-DSPE, and were obtained in much better yield than similar suspensions with PEG-phospholipid and commonly used thiol-PEG. These suspensions were also stable to PBS, serum, and a variety of pHs after removal of excess polymer. Dextran-DSPE thus shows great promise as a general surfactant material for the functionalization of a variety of nanomaterials, which could facilitate future biological applications.
Dai* Hongjie
Goodwin Andrew P.
Prencipe Giuseppe
Sherlock Sarah P.
Tabakman Scott M.
No associations
LandOfFree
Phospholipid-Dextran with a Single Coupling Point: a Useful Amphiphile for Functionalization of Nanomaterials does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Phospholipid-Dextran with a Single Coupling Point: a Useful Amphiphile for Functionalization of Nanomaterials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phospholipid-Dextran with a Single Coupling Point: a Useful Amphiphile for Functionalization of Nanomaterials will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-663117