Pathways of mechanical unfolding of FnIII_{10}: low force intermediates

Details Pathways of mechanical unfolding of FnIII_{10}: low force intermediates Pathways of mechanical unfolding of FnIII_{10}: low force intermediates

2010-06-16

arxiv.org/abs/1006.3287v1

J. Chem. Phys. 133, 065101 (2010)

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

10.1063/1.3464476

We study the mechanical unfolding pathways of the $FnIII_{10}$ domain of fibronectin by means of an Ising--like model, using both constant force and constant velocity protocols. At high forces and high velocities our results are consistent with experiments and previous computational studies. Moreover, the simplicity of the model allows us to probe the biologically relevant low force regime, where we predict the existence of two intermediates with very close elongations. The unfolding pathway is characterized by stochastic transitions between these two intermediates.

Affiliated with

Also associated with

No associations

Rating

Pathways of mechanical unfolding of FnIII_{10}: low force intermediates does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Pathways of mechanical unfolding of FnIII_{10}: low force intermediates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pathways of mechanical unfolding of FnIII_{10}: low force intermediates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-101150