Origins of Chevron Rollovers in Non-Two-State Protein Folding Kinetics

Details Origins of Chevron Rollovers in Non-Two-State Protein Folding Kinetics Origins of Chevron Rollovers in Non-Two-State Protein Folding Kinetics

2003-02-14

arxiv.org/abs/cond-mat/0302305v2

Physical Review Letters 90, 258104 (2003).

Physics

Condensed Matter

Soft Condensed Matter

10 pages, 4 Postscript figures (will appear on PRL)

Scientific paper

10.1103/PhysRevLett.90.258104

Chevron rollovers of some proteins imply that their logarithmic folding rates are nonlinear in native stability. This is predicted by lattice and continuum G\=o models to arise from diminished accessibilities of the ground state from transiently populated compact conformations under strongly native conditions. Despite these models' native-centric interactions, the slowdown is due partly to kinetic trapping caused by some of the folding intermediates' nonnative topologies. Notably, simple two-state folding kinetics of small single-domain proteins are not reproduced by common G\=o-like schemes.

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