On the statistical mechanics of prion diseases

Details On the statistical mechanics of prion diseases On the statistical mechanics of prion diseases

2001-02-26

arxiv.org/abs/cond-mat/0102478v1

Physics

Condensed Matter

Statistical Mechanics

5 Pages, 3 eps figures (submitted to Physical Review Letters)

Scientific paper

10.1103/PhysRevLett.87.058101

We simulate a two-dimensional, lattice based, protein-level statistical mechanical model for prion diseases (e.g., Mad Cow disease) with concommitant prion protein misfolding and aggregation. Our simulations lead us to the hypothesis that the observed broad incubation time distribution in epidemiological data reflect fluctuation dominated growth seeded by a few nanometer scale aggregates, while much narrower incubation time distributions for innoculated lab animals arise from statistical self averaging. We model `species barriers' to prion infection and assess a related treatment protocol.

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