On the form of growing strings

Details On the form of growing strings On the form of growing strings

2005-08-26

arxiv.org/abs/cond-mat/0508628v1

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 3 figures. Accepted for publication in Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.95.098103

Patterns and forms adopted by Nature, such as the shape of living cells, the geometry of shells and the branched structure of plants, are often the result of simple dynamical paradigms. Here we show that a growing self-interacting string attached to a tracking origin, modeled to resemble nascent polypeptides in vivo, develops helical structures which are more pronounced at the growing end. We also show that the dynamic growth ensemble shares several features of an equilibrium ensemble in which the growing end of the polymer is under an effective stretching force. A statistical analysis of native states of proteins shows that the signature of this non-equilibrium phenomenon has been fixed by evolution at the C-terminus, the growing end of a nascent protein. These findings suggest that a generic non-equilibrium growth process might have provided an additional evolutionary advantage for nascent proteins by favoring the preferential selection of helical structures.

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