Non-native beta-sheet formation: insights into protein amyloidosis

Details Non-native beta-sheet formation: insights into protein amyloidosis Non-native beta-sheet formation: insights into protein amyloidosis

2002-03-08

arxiv.org/abs/cond-mat/0203200v1

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

Protein amyloidosis is a cytopathological process characterized by the formation of highly beta-sheet-rich fibrils. How this process occurs and how to prevent/treat the associated diseases are not completely understood. Here, we carry out a theoretical investigation of sequence-independent beta-sheet formation, based on recent findings regarding the cooperativity of hydrogen-bond network formation. Our results strongly suggest that in vivo beta-sheet aggregation is induced by inter-sheet stacking dynamics. This leads to a prediction for the minimal length of susceptible polymer needed to form such an aggregate. Remarkably, the prediction corresponds quite well with the critical lengths detected in poly-glutamine-related diseases. Our work therefore provides a theoretical framework capable of understanding the underlying mechanism and shedding light on therapy strategies of protein amyloidosis.

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