Mutagenesis and Metallic DNA

Details Mutagenesis and Metallic DNA Mutagenesis and Metallic DNA

2000-08-10

arxiv.org/abs/cond-mat/0008166v1

Physics

Condensed Matter

Strongly Correlated Electrons

4 pages, 2 Figures

Scientific paper

Positions of protons in DNA hydrogen bonds are fundamental for the fidelity of the replication process. Because the hydrogen bond is partially covalent the electronic structure of DNA plays an important role in the replication process. Current studies of electron transfer in DNA have shown that simple pictures based on independent electron physics are not sufficient to account for the experimental data. In this paper we propose a model for electron-proton interaction in DNA and its relationship to mutagenesis. We argue that mutations will be more frequent in DNA sequences where electron delocalization occurs. To test our theory we calculate the heat capacity of DNA at low temperatures and compare with the available experimental data in hydrated DNA. We find that our model is in good agreement with the data. We also propose new measurements of infrared absorption which would further test our ideas.

Affiliated with

Also associated with

No associations

Rating

Mutagenesis and Metallic DNA does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Mutagenesis and Metallic DNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutagenesis and Metallic DNA will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-724002