Physics – Condensed Matter – Materials Science
Scientific paper
2008-09-13
Physics
Condensed Matter
Materials Science
Journal of the American Chemical Society, in press
Scientific paper
We show that single walled carbon nanotubes with different isotope compositions exhibit distinct Raman Gband peaks and can be used for multiplexed multi-color Raman imaging of biological systems. Cancer cells with specific receptors are selectively labeled with 3 differently colored SWNTs conjugated with various targeting ligands including Herceptin, anti-Her2, Erbitux, anti-Her1, and RGD peptide, allowing for multi-color Raman imaging of cells in a multiplexed manner. SWNT Raman signals are highly robust against photo-bleaching, allowing long term imaging and tracking. With narrow peak features, SWNT Raman signals are easily differentiated from the auto-fluorescence background. The SWNT Raman excitation and scattering photons are in the near-infrared region, which is the most transparent optical window for biological systems in vitro and in vivo. Thus, SWNTs are novel Raman tags promising for multiplexed biological detection and imaging.
Dai* Hongjie
Fan Shoushan
Jiang Kaili
Li Xiaolin
Liu Zhuang
No associations
LandOfFree
Multiplexed Multi-Color Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Multiplexed Multi-Color Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multiplexed Multi-Color Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-156121