Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2011-04-17
Phys. Rev. E 84, 011914 (2011)
Physics
Condensed Matter
Statistical Mechanics
13 pages, 8 figures, 1 Table
Scientific paper
10.1103/PhysRevE.84.011914
We model analytically the dynamics of a cytoskeletal filament in a motility assay. The filament is described as rigid rod free to slide in two dimensions. The motor proteins consist of polymeric tails tethered to the plane and modeled as linear springs and motor heads that bind to the filament. As in related models of rigid and soft two-state motors, the binding/unbinding dynamics of the motor heads and the dependence of the transition rates on the load exerted by the motor tails play a crucial role in controlling the filament's dynamics. Our work shows that the filament effectively behaves as a self-propelled rod at long times, but with non-Markovian noise sources arising from the coupling to the motor binding/unbinding dynamics. The effective propulsion force of the filament and the active renormalization of the various friction and diffusion constants are calculated in terms of microscopic motor and filament parameters. These quantities could be probed by optical force microscopy.
Banerjee Shiladitya
Marchetti Cristina M.
Müller-Nedebock Kristian
No associations
LandOfFree
Motor-driven Dynamics of Cytoskeletal FIlaments in Motility Assays does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Motor-driven Dynamics of Cytoskeletal FIlaments in Motility Assays, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Motor-driven Dynamics of Cytoskeletal FIlaments in Motility Assays will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-71264