Microscopic implications of S-DNA

Details Microscopic implications of S-DNA Microscopic implications of S-DNA

2010-02-10

arxiv.org/abs/1002.2169v2

Phys. Rev. E 82, 021907 (2010)

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

10.1103/PhysRevE.82.021907

Recent experiments [J. van Mameren et al. PNAS 106, 18231 (2009)] provide a detailed spatial picture of overstretched DNA, showing that under certain conditions the two strands of the double helix separate at about 65 pN. It was proposed that this observation rules out the existence of an elongated, hybridized form of DNA ('S-DNA'). Here we argue that the S-DNA picture is consistent with the observation of unpeeling during overstretching. We demonstrate that assuming the existence of S-DNA does not imply DNA overstretching to consist of the complete or near-complete conversion of the molecule from B- to S-form. Instead, this assumption implies in general a more complex dynamic coexistence of hybridized and unhybridized forms of DNA. We argue that such coexistence can rationalize several recent experimental observations.

Affiliated with

Also associated with

No associations

Rating

Microscopic implications of S-DNA does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Microscopic implications of S-DNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microscopic implications of S-DNA will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-239579