Mechanisms underlying sequence-independent beta-sheet formation

Details Mechanisms underlying sequence-independent beta-sheet formation Mechanisms underlying sequence-independent beta-sheet formation

2001-04-03

arxiv.org/abs/cond-mat/0104065v2

Physics

Condensed Matter

Soft Condensed Matter

20 pages, 5 figures, Revtex4, simulation mpeg movie available at http://www-physics.ucsd.edu/~guochin/Images/sheet1.mpg

Scientific paper

10.1063/1.1448493

We investigate the formation of beta-sheet structures in proteins without taking into account specific sequence-dependent hydrophobic interactions. To accomplish this, we introduce a model which explicitly incorporates both solvation effects and the angular dependence (on the protein backbone) of hydrogen bond formation. The thermodynamics of this model is studied by comparing the restricted partition functions obtained by "unfreezing" successively larger segments of the native beta-sheet structure. Our results suggest that solvation dynamics together with the aforementioned angular dependence gives rise to a generic cooperativity in this class of systems; this result explains why pathological aggregates involving beta-sheet cores can form from many different proteins. Our work provides the foundation for the construction of phenomenological models to investigate the competition between native folding and non-specific aggregation.

Affiliated with

Also associated with

No associations

Rating

Mechanisms underlying sequence-independent beta-sheet formation does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Mechanisms underlying sequence-independent beta-sheet formation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mechanisms underlying sequence-independent beta-sheet formation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-291716