Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2006-10-11
J. Chem. Phys. 126, 095103 (2007)
Physics
Condensed Matter
Soft Condensed Matter
final version after minor revisions
Scientific paper
10.1063/1.2464080
Motivated by cell adhesion in hydrodynamic flow, here we study bond formation between a spherical Brownian particle in linear shear flow carrying receptors for ligands covering the boundary wall. We derive the appropriate Langevin equation which includes multiplicative noise due to position-dependent mobility functions resulting from the Stokes equation. We present a numerical scheme which allows to simulate it with high accuracy for all model parameters, including shear rate and three parameters describing receptor geometry (distance, size and height of the receptor patches). In the case of homogeneous coating, the mean first passage time problem can be solved exactly. In the case of position-resolved receptor-ligand binding, we identify different scaling regimes and discuss their biological relevance.
Korn Ch.
Schwarz Ulrich S.
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