Magnetophoresis of Flexible DNA-based Dumbbell Structures

Details Magnetophoresis of Flexible DNA-based Dumbbell Structures Magnetophoresis of Flexible DNA-based Dumbbell Structures

2008-01-02

arxiv.org/abs/0801.0338v1

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 3 figures, preprint, to be published in APL

Scientific paper

10.1063/1.2834698

Controlled movement and manipulation of magnetic micro and nanostructures using magnetic forces can give rise to important applications in biomedecine, diagnostics and immunology. We report controlled magnetophoresis and stretching, in aqueous solution, of a DNA-based dumbbell structure containing magnetic and diamagnetic microspheres. The velocity and stretching of the dumbbell were experimentally measured and correlated with a theoretical model based on the forces acting on individual magnetic beads or the entire dumbbell structures. The results show that precise and predictable manipulation of dumbbell structures is achievable and can potentially be applied to immunomagnetic cell separators.

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