Machinery of Functional Dynamics in Native Proteins

Details Machinery of Functional Dynamics in Native Proteins Machinery of Functional Dynamics in Native Proteins

2003-09-19

arxiv.org/abs/cond-mat/0309448v1

Physics

Condensed Matter

Soft Condensed Matter

13 pages with 4 figures; submitted to Phys. Rev. Lett

Scientific paper

We provide evidence that the energy landscapes of folded proteins do not shift with temperature, but the onset of functional dynamics is associated with its effective sampling. The motion of the backbone is described by three distinct regimes. One is associated with slow time scales of the activity along the envelope of the energy surface defining the folded protein. Another, with fast time scales, is due to activity along the pockets decorating the folded-state envelope. The intermediate regime emerges at temperatures where jumps between the pockets become possible, leading to an active protein.

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