Lateral Separation of Macromolecules and Polyelectrolytes in Microlithographic Arrays

Details Lateral Separation of Macromolecules and Polyelectrolytes in Microlithographic Arrays Lateral Separation of Macromolecules and Polyelectrolytes in Microlithographic Arrays

1997-06-18

arxiv.org/abs/cond-mat/9706192v1

Phys. Rev. Lett. 80, 1548 (1998).

Physics

Condensed Matter

Soft Condensed Matter

4 pages with 3 eps figures, needs RevTeX 3.0 and epsf, also available in postscript form http://cmtw.harvard.edu/~deniz/

Scientific paper

10.1103/PhysRevLett.80.1548

A new approach to separation of a variety of microscopic and mesoscopic objects in dilute solution is presented. The approach takes advantage of unique properties of a specially designed separation device (sieve), which can be readily built using already developed microlithographic techniques. Due to the broken reflection symmetry in its design, the direction of motion of an object in the sieve varies as a function of its self-diffusion constant, causing separation transverse to its direction of motion. This gives the device some significant and unique advantages over existing fractionation methods based on centrifugation and electrophoresis.

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