Kinetics of proton pumping in cytochrome c oxidase

Details Kinetics of proton pumping in cytochrome c oxidase Kinetics of proton pumping in cytochrome c oxidase

2008-12-09

arxiv.org/abs/0812.1785v4

J. Chem. Phys. 130, 235105 (2009)

Physics

Condensed Matter

Other Condensed Matter

32 pages, 4 figures; references added. Minor changes in the Acknowledgements section

Scientific paper

We propose a simple model of cytochrome c oxidase, including four redox centers and four protonable sites, to study the time evolution of electrostatically coupled electron and proton transfers initiated by the injection of a single electron into the enzyme. We derive a system of master equations for electron and proton state probabilities and show that an efficient pumping of protons across the membrane can be obtained for a reasonable set of parameters. All four experimentally observed kinetic phases appear naturally from our model. We also calculate the dependence of the pumping efficiency on the transmembrane voltage at different temperatures and discuss a possible mechanism of the redox-driven proton translocation.

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