Investigating the thermodynamics of small biosystems with optical tweezers

Details Investigating the thermodynamics of small biosystems with optical tweezers Investigating the thermodynamics of small biosystems with optical tweezers

2009-04-21

arxiv.org/abs/0904.3197v1

Physica E 42, 666 (2010)

Physics

Condensed Matter

Mesoscale and Nanoscale Physics

6 pages, 9 figures, Proceedings of the conference Frontiers of Quantum and Mesoscopic Thermodynamics, Prague 2008

Scientific paper

10.1016/j.physe.2009.06.055

We present two examples of how single-molecule experimental techniques applied to biological systems can give insight into problems within the scope of equilibrium and nonequilibrium mesoscopic thermodynamics. The first example is the mapping of the free energy landscape of a macromolecule, the second the experimental verification of Crooks' fluctuation theorem. In both cases the experimental setup comprises optical tweezers and DNA molecules.

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