Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics

Details Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics

2006-07-14

arxiv.org/abs/cond-mat/0607384v2

Physics

Condensed Matter

Soft Condensed Matter

6 pages, 5 figures, revised version

Scientific paper

We have studied the adsorption kinetics of the protein amylase at solid/liquid interfaces. Offering substrates with tailored properties, we are able to separate the impact of short- and long-range interactions. By means of a colloidal Monte Carlo approach including conformational changes of the adsorbed proteins induced by density fluctuations, we develop a scenario that is consistent with the experimentally observed three-step kinetics on specific substrates. Our observations show that not only the surface chemistry determines the properties of an adsorbed protein layer but also the van der Waals contributions of a composite substrate may lead to non-negligible effects.

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