Hierarchical organization of modularity in metabolic networks

Details Hierarchical organization of modularity in metabolic networks Hierarchical organization of modularity in metabolic networks

2002-09-10

arxiv.org/abs/cond-mat/0209244v1

Science 297 (2002), pp. 1551-1555

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

10.1126/science.1073374

Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, their number and degree of clustering following a power law. Within Escherichia coli the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization.

Affiliated with

Also associated with

No associations

Rating

Hierarchical organization of modularity in metabolic networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Hierarchical organization of modularity in metabolic networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hierarchical organization of modularity in metabolic networks will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-368694