Heteropolymer translocation through nanopores

Details Heteropolymer translocation through nanopores Heteropolymer translocation through nanopores

2007-01-22

arxiv.org/abs/cond-mat/0701522v1

J. Chem. Phys. 126, 145101 (2007)

Physics

Condensed Matter

Soft Condensed Matter

13 Pages, 6 Figures

Scientific paper

10.1063/1.2719198

We investigate the translocation dynamics of heteropolymers driven through a nanopore using a constant temperature Langevin thermostat. Specifically, we consider heteropolymers consisting of two types of monomers labeled A and B, which are distinguished by the magnitude of the driving force that they experience inside the pore. From a series of studies on polymers with sequences AnBn+m we identify both universal as well as sequence specific properties of the translocating chains. We find that the scaling of the average translocation time as a function of the chain length N remains unaffected by the heterogeneity, while the residence time of each bead is a strong function of the sequence for short repeat units. We further discover that for a symmetric heteropolymer AnBn of fixed length, the pattern exhibited by the residence time of the individual monomer has striking similarity with an interference pattern for an optical grating with N/(2n) slits. These results are relevant for designing nanopore based sequencing techniques.

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