Green fluorescent proteins as optically-controllable elements in bioelectronics

Details Green fluorescent proteins as optically-controllable elements in bioelectronics Green fluorescent proteins as optically-controllable elements in bioelectronics

2001-07-27

arxiv.org/abs/cond-mat/0107576v1

Physics

Condensed Matter

8 pages, 3 figures

Scientific paper

10.1063/1.1419047

A single-biomolecule optical toggle-switch is demonstrated based on a mutated green fluorescent protein (GFP). We have exploited molecular biology techniques to tailor GFP molecular structure and photophysical properties and give it optically-controlled bistability between two distinct states. We present optical control of the fluorescence dynamics with two laser beams at 476 and 350 nm down to the ultimate limit of single molecules. These results indicate that GFP-class fluorophores are promising candidates for the realization of biomolecular devices such as volumetric optical memories and optical switches.

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