Genetic Toggle Switch Without Cooperative Binding

Details Genetic Toggle Switch Without Cooperative Binding Genetic Toggle Switch Without Cooperative Binding

2006-03-22

arxiv.org/abs/q-bio/0603026v1

Biology

Quantitative Biology

Molecular Networks

10 pages,4 figures

Scientific paper

10.1103/PhysRevLett.96.188101

Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.

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