Gating-by-tilt of mechanosensitive membrane channels

Details Gating-by-tilt of mechanosensitive membrane channels Gating-by-tilt of mechanosensitive membrane channels

2003-11-25

arxiv.org/abs/cond-mat/0311574v1

Physics

Condensed Matter

Soft Condensed Matter

10 pages, 2 figures

Scientific paper

10.1103/PhysRevLett.93.118103

We propose an alternative mechanism for the gating of biological membrane channels in response to membrane tension that involves a change in the slope of the membrane near the channel. Under biological membrane tensions we show that the energy difference between the closed (tilted) and open (untilted) states can far exceed kBT and is comparable to what is available under simple ilational gating. Recent experiments demonstrate that membrane leaflet asymmetries (spontaneous curvature) can strong effect the gating of some channels. Such a phenomenon would be more easy to explain under gating-by-tilt, given its novel intrinsic sensitivity to such asymmetry.

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