Force-clamp spectroscopy of reversible bond breakage

Details Force-clamp spectroscopy of reversible bond breakage Force-clamp spectroscopy of reversible bond breakage

2008-07-30

arxiv.org/abs/0807.4813v1

Physics

Condensed Matter

Soft Condensed Matter

8 pages, 4 figures

Scientific paper

10.1063/1.3071199

We consider reversible breaking of adhesion bonds or folding of proteins under the influence of a constant external force. We discuss the stochastic properties of the unbinding/rebinding events and analyze their mean number and their variance in the framework of simple two-state models. In the calculations, we exploit the analogy to single molecule fluorescence and particularly between unbinding/rebinding and photon emission events. Environmental fluctuation models are used to describe deviations from Markovian behavior. The second moment of the event-number distribution is found to be very sensitive to possible exchange processes and can thus be used to identify temporal fluctuations of the transition rates.

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