Focal adhesion: Physics of a Biological Mechano-Sensor

Details Focal adhesion: Physics of a Biological Mechano-Sensor Focal adhesion: Physics of a Biological Mechano-Sensor

2003-06-04

arxiv.org/abs/cond-mat/0306116v1

Biophys. J. 83, 3079 (2002)

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 2 figures

Scientific paper

Mechanical coupling between a cell and substrate relies on focal adhesions, clusters of adhesion proteins linking stress fibers (bundles of actin proteins) inside the cell with surrounding tissue. Focal adhesions have been demonstrated to both measure and regulate the mechanical traction along the stress fibers. We present a quantitative model for focal adhesion mechano-sensing and stress regulation based on stress amplification at the critical point of a condensation transition of the adhesion proteins.

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