Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2003-06-04
Biophys. J. 83, 3079 (2002)
Physics
Condensed Matter
Soft Condensed Matter
4 pages, 2 figures
Scientific paper
Mechanical coupling between a cell and substrate relies on focal adhesions, clusters of adhesion proteins linking stress fibers (bundles of actin proteins) inside the cell with surrounding tissue. Focal adhesions have been demonstrated to both measure and regulate the mechanical traction along the stress fibers. We present a quantitative model for focal adhesion mechano-sensing and stress regulation based on stress amplification at the critical point of a condensation transition of the adhesion proteins.
Bickel Thomas
Bruinsma Robijn
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