Finding the optimum activation energy in DNA breathing dynamics: A Simulated Annealing approach

Details Finding the optimum activation energy in DNA breathing dynamics: A Simulated Annealing approach Finding the optimum activation energy in DNA breathing dynamics: A Simulated Annealing approach

2009-07-07

arxiv.org/abs/0907.1140v1

J. Phys. A: Math. Theor. 42 (2009) 335101

Physics

Condensed Matter

Statistical Mechanics

9 pages, 4 figures, iop article package included

Scientific paper

10.1088/1751-8113/42/33/335101

We demonstrate how the stochastic global optimization scheme of Simulated Annealing can be used to evaluate optimum parameters in the problem of DNA breathing dynamics. The breathing dynamics is followed in accordance with the stochastic Gillespie scheme with the denaturation zones in double stranded DNA studied as a single molecule time series. Simulated Annealing is used to find the optimum value of the activation energy for which the equilibrium bubble size distribution matches with a given value. It is demonstrated that the method overcomes even large noise in the input surrogate data.

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