Filamin cross-linked semiflexible networks: Fragility under strain

Details Filamin cross-linked semiflexible networks: Fragility under strain Filamin cross-linked semiflexible networks: Fragility under strain

2006-01-31

arxiv.org/abs/cond-mat/0602005v2

Physics

Condensed Matter

Soft Condensed Matter

4 Pages, 3 figures, Revtex4, submitted to PRL

Scientific paper

10.1103/PhysRevLett.97.068104

The semiflexible F-actin network of the cytoskeleton is cross-linked by a variety of proteins including filamin, which contain Ig-domains that unfold under applied tension. We examine a simple semiflexible network model cross-linked by such unfolding linkers that captures the main mechanical features of F-actin networks cross-linked by filamin proteins and show that under sufficiently high strain the network spontaneously self-organizes so that an appreciable fraction of the filamin cross-linkers are at the threshold of domain unfolding. We propose an explanation of this organization based on a mean-field model and suggest a qualitative experimental signature of this type of network reorganization under applied strain that may be observable in intracellular microrheology experiments of Crocker et al.

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