Fast DNA Sequencing via Transverse Electronic Transport

Details Fast DNA Sequencing via Transverse Electronic Transport Fast DNA Sequencing via Transverse Electronic Transport

2006-01-18

arxiv.org/abs/cond-mat/0601394v2

Nano Lett. 6, 779 (2006)

Physics

Condensed Matter

Soft Condensed Matter

5 pages, 3 figures

Scientific paper

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, e.g., orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict and cure diseases from the perspective of the genetic makeup of each individual.

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