Factors governing fibrillogenesis of polypeptide chains

Details Factors governing fibrillogenesis of polypeptide chains Factors governing fibrillogenesis of polypeptide chains

2010-11-05

arxiv.org/abs/1011.1454v1

Physics

Condensed Matter

Soft Condensed Matter

10 pages, 7 figures

Scientific paper

Using lattice models we explore the factors that determine the tendencies of polypeptide chains to aggregate by exhaustively sampling the sequence and conformational space. The morphologies of the fibril-like structures and the time scales ($\tau_{fib}$) for their formation depend on a balance between hydrophobic and coulomb interactions. The extent of population of an ensemble of \textbf{N$^*$} structures, which are fibril-prone structures in the spectrum of conformations of an isolated protein, is the major determinant of $\tau_{fib}$. This observation is used to determine the aggregating sequences by exhaustively exploring the sequence space, thus providing a basis for genome wide search of fragments that are aggregation prone.

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