Facilitated diffusion of proteins on chromatin

Details Facilitated diffusion of proteins on chromatin Facilitated diffusion of proteins on chromatin

2010-06-24

arxiv.org/abs/1006.4758v2

Phys. Rev. Lett. 106, 038102 (2011)

Physics

Condensed Matter

Statistical Mechanics

4 pages, 4 figures, accepted version

Scientific paper

We present a theoretical model of facilitated diffusion of proteins in the cell nucleus. This model, which takes into account the successive binding/unbinding events of proteins to DNA, relies on a fractal description of the chromatin which has been recently evidenced experimentally. Facilitated diffusion is shown quantitatively to be favorable for a fast localization of a target locus by a transcription factor, and even to enable the minimization of the search time by tuning the affinity of the transcription factor with DNA. This study shows the robustness of the facilitated diffusion mechanism, invoked so far only for linear conformations of DNA.

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