Equilibrium properties and force-driven unfolding pathways of RNA molecules

Details Equilibrium properties and force-driven unfolding pathways of RNA molecules Equilibrium properties and force-driven unfolding pathways of RNA molecules

2009-10-27

arxiv.org/abs/0910.5089v1

Phys. Rev. Lett. 103: 188102 (2009)

Physics

Condensed Matter

Soft Condensed Matter

Main text + appendix, to appear in Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.103.188102

The mechanical unfolding of a simple RNA hairpin and of a 236--bases portion of the Tetrahymena thermophila ribozyme is studied by means of an Ising--like model. Phase diagrams and free energy landscapes are computed exactly and suggest a simple two--state behaviour for the hairpin and the presence of intermediate states for the ribozyme. Nonequilibrium simulations give the possible unfolding pathways for the ribozyme, and the dominant pathway corresponds to the experimentally observed one.

Affiliated with

Also associated with

No associations

Rating

Equilibrium properties and force-driven unfolding pathways of RNA molecules does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Equilibrium properties and force-driven unfolding pathways of RNA molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Equilibrium properties and force-driven unfolding pathways of RNA molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-482900