Enhancing protein drop stability for crystallization by chemical patterning

Details Enhancing protein drop stability for crystallization by chemical patterning Enhancing protein drop stability for crystallization by chemical patterning

2006-04-12

arxiv.org/abs/cond-mat/0604326v1

Acta Crystallographica Section D (2005) 61, 1563

Physics

Condensed Matter

Soft Condensed Matter

text 4 pages, 6 jpg figures

Scientific paper

10.1107/S0907444905028866

Motion of protein drops on crystallization media during routine handling is a major factor affecting the reproducibility of crystallization conditions. Drop stability can be enhanced by chemical patterning to more effectively pin the drop's contact line. As an example, a hydrophilic area is patterned on an initially flat hydrophobic glass slide. The drop remains confined to the hydrophilic area, and the maximum drop size that remains stable when the slide is rotated to the vertical position increases. This simple method is readily scalable and has the potential to significantly improve outcomes in hanging and sitting drop crystallization.

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