Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2011-12-02
Physics
Condensed Matter
Soft Condensed Matter
7 pages, 8 figures, accepted in the Journal of Chemical Physics
Scientific paper
10.1063/1.3673439
Biopolymer looping is a dynamic process that occurs ubiquitously in cells for gene regulation, protein folding, etc. In cellular environments, biopolymers are often subject to tensions which are either static, or temporally fluctuating far away from equilibrium. We study the dynamics of semiflexible polymer looping in the presence of such tensions by using Brownian dynamics simulation combined with an analytical theory. We show a minute tension dramatically changes the looping time, especially for long chains. Considering a dichotomically flipping noise as a simple example of the nonequilibrium tension, we find the phenomenon of resonant activation, where the looping time can be the minimum at an optimal flipping time. We discuss our results in connection with recent experiments.
Shin Jaeoh
Sung Wokyung
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