Effects of Sequence Disorder on DNA Looping and Cyclization

Details Effects of Sequence Disorder on DNA Looping and Cyclization Effects of Sequence Disorder on DNA Looping and Cyclization

2005-10-12

arxiv.org/abs/cond-mat/0510302v5

Physical Review E, 76, 021901 (2007)

Physics

Condensed Matter

Soft Condensed Matter

8 pages, 4 figures, LaTeX; accepted to Physical Review E; v2: a substantially revised version; v3: references added, conclusio

Scientific paper

Effects of sequence disorder on looping and cyclization of the double-stranded DNA are studied theoretically. Both random intrinsic curvature and inhomogeneous bending rigidity are found to result in a remarkably wide distribution of cyclization probabilities. For short DNA segments, the range of the distribution reaches several orders of magnitude for even completely random sequences. The ensemble averaged values of the cyclization probability are also calculated, and the connection to the recent experiments is discussed.

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