Dynamic modeling of gene expression data

Details Dynamic modeling of gene expression data Dynamic modeling of gene expression data

2001-02-15

arxiv.org/abs/cond-mat/0102267v1

Proc. Natl. Acad. Sci. 98, 1693-1698 (2001)

Physics

Condensed Matter

Statistical Mechanics

REVTex, 3 figures

Scientific paper

10.1073/pnas.98.4.1693

We describe the time evolution of gene expression levels by using a time translational matrix to predict future expression levels of genes based on their expression levels at some initial time. We deduce the time translational matrix for previously published DNA microarray gene expression data sets by modeling them within a linear framework using the characteristic modes obtained by singular value decomposition. The resulting time translation matrix provides a measure of the relationships among the modes and governs their time evolution. We show that a truncated matrix linking just a few modes is a good approximation of the full time translation matrix. This finding suggests that the number of essential connections among the genes is small.

Affiliated with

Also associated with

No associations

Rating

Dynamic modeling of gene expression data does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Dynamic modeling of gene expression data, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dynamic modeling of gene expression data will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-202666