Dose-dependent biological damage of tumour cells by laser-accelerated proton beams

Details Dose-dependent biological damage of tumour cells by laser-accelerated proton beams Dose-dependent biological damage of tumour cells by laser-accelerated proton beams

Aug 2010

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2010njph...12h5003k&link_type=abstract

New Journal of Physics, Volume 12, Issue 8, pp. 085003 (2010).

Physics

6

Scientific paper

We report on the first irradiation of in vitro tumour cells with laser-accelerated proton pulses showing dose-dependent biological damage. This experiment, paving the way for future radiobiological studies with laser-accelerated protons, demonstrates the simultaneous availability of all the components indispensable for systematic radiobiological studies: a laser-plasma accelerator providing proton spectra with maximum energy exceeding 15 MeV and applicable doses of a few Gy within a few minutes; a beam transport and filtering system; an in-air irradiation site; and a dosimetry system providing both online dose monitoring and absolute dose information applied to the cell sample and the full infrastructure for analysing radiation-induced damage in cells.

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